Exosome Therapy

The Future of Healthcare

What is an exosome?

Exosomes are so-called extracellular vesicles, or small bubbles, released from cells, especially from stem cells. They act as shuttles for certain genetic information and proteins to other cells.
They allow for cell-to-cell communication, transporting molecules that are important regulators of intracellular information between close and distant cells. They carry information from place to place with different functions and purposes telling cells how and when to react.
Exosomes are being heralded as the next frontier of cell therapy. While not being cells at all, they play a vital role in the communication and rejuvenation of all the cells in our body. Science has shown that the cell-to-cell communication is important in maintaining a healthy cellular terrain.
Age, chronic disease, environmental factors and genetic disorders can interfere with how our stem cells communicate with other cells, thus disrupting the healing process. Exosomes play a key role in the regulation of these communication processes.

What are the functions of an Exosome?

Exosomes mediate further infection and degeneration.  They have the ability to transfer pathogen-related molecules(pathogenic genes and proteins) or even the entire pathogen.  They can mediate toxic reactions.  When released by regenerative cells, such as stem cells, for example, are potent drivers of healing and repair. 

How do Exosomes differ from stem cells?

Exosomes are being described as the ‘secret sauce’ of stem cells…. Exosomes cannot replicate; they cannot transform into malignant cells or other harmful cell types; they are less likely to trigger an immunogenic response; they cannot be infected with a virus. MORE INFO

How Do Exosomes Work?

Exosomes are extracellular vesicles, or small bubbles, released from cells that act as shuttles for genetic information, proteins and messenger RNA to other cells. This usually happens in response to injuries. Generally speaking, Exosomes carry healthy and lost information and insert this to target cells. Exosomes rele
ased by young stem cells have shown to be very powerful in regulating regenerative processes in the body and assisting in rejuvenation.
Exosomes from stem cells contain valuable cell information consisting of proteins and genetic information the cell needs to function correctly. These stem cell derived Exosomes have also shown to assist in transferring NK cells (Killer cells) into T-Regulator cells (Helper cells) By that they assist in calming an overreactive immune system and modulating it to respond in a coordinated fashion. They can also be used as a delivery system for medication.

How do they get the Exosomes?

Exosomes are sourced from laboratory grade, GMP certified mesenchymal stem cells. Several accepted techniques, such as differential ultracentrifugation, density gradients, precipitation, filtration, and size exclusion chromatography, have been applied for exosome separation.  Our Exosomes are extracted using the ultracentrifugation technique.

What conditions are good for Regenerative therapy with Exosomes?

Exosome therapy is a minimally invasive procedure commonly used in orthopedic injuries, for anti-aging and  other degenerative diseases. … Exosome therapy can be injected into the affected area like in orthopedic injuries or given intravenously for anti-aging and hair loss.
These exosome therapies are either delivered by intravenous infusion for chronic or systemic (full-body) conditions or inner-articular for joint conditions.
Patients with Lyme disease, chronic inflammation, autoimmune disease and other chronic degenerative diseases may benefit from including exosomes in their treatment regimen.
We aren’t diagnosing you with your condition but administering the Exosomes to help your body with your condition.

How Are the Exosomes Screened For Safety? Is There Any Risk of Viruses Being Passed on Through Exosomes?

The starting material (mesenchymal stem cells) are GMP laboratory grade, meaning they have been screened for disease, viruses and bacteria. Once the exosomes have been extracted, the stem cells are discarded. The finished exosomes solution is sterile filtered and tested according to the standard pharmaceutical regulations for sterility.

Is There Any Theoretical Risk of the Body Rejecting Exosomes with Them Being a Foreign Substance?

This is extremely unlikely as there are no immune markers on the surface of the exosomes. They are not cells or tissue. It may be possible to experience die-off reaction after receiving exosomes as these activate the natural killer cells to become T-Regulator cells. For this reason, we always give a small test dose before applying a larger dose.

Will People Need Multiple Rounds of Exosomes, and If So, How Should They Be Spaced Apart?

Some cases a follow-up treatment may be advised. There is no sustainable data about standard dosing and the treatment is as individual as the response. Some patients may need a single application, while others need multiple doses or a small booster therapy. In some cases, therapy may start with a small initial dose which is increased over time. MORE INFO

How fast will I see results from Exosome therapy?

Exosomes trigger a so-called bi-phasic response. First, an immediate reaction. This usually last about 24 hours until the initial proteins have been broken down. Then the messenger RNA, which has been inserted into the target cells becomes active and helps ‘reprogram’ the cell. This usually takes 6-8 weeks. So the timeline is about 8-10 weeks. The continued effects may continue for months afterwards.

What are the risks or contra-indications for Exosome therapy?

Exosome therapy is usually performed on an outpatient basis. Most patients should expect to leave the clinic without any down time. The patient will not experience any discomfort. Less than 10% of patients have reported developing a mild fever, headache, nausea or vomiting. However, these side effects have never lasted more than three days and usually resolve within 24 hours. No long-term negative side effects have been reported. MORE INFO

When Can I Resume Physical Activity?

In order to gain an optimal response from exosome therapy, we recommend the following:
Refraining from anti-inflammatory medication
No over strenuous activity for the first 24–48 hours
Resume cardio workouts after 3–4 weeks
After four weeks resume any weight lifting and running activity if part of your prior routine

Are Exosomes FDA approved?

Currently, Exosomes are not FDA approved.  Nor are stem cells and Vitamins/Minerals.

Can Exosomes Cause Cancer?

Cancer Exosomes can cause cancer to grow. These are not to be confused with exosomes derived from stem cells which we use in treatment. Stem cell derived exosomes can actually
be indicated in the treatment of some cancers as they can insert the missing proteins into the cancer cells and stop their replication.

Do Exosomes Help Chronic Inflammation?

Recent research has shown that stem cell-derived exosomes have an anti-inflammatory potential and induce high levels of anti- inflammatory cytokines and can therefore assist to regulate the inflammatory response. In addition, they can also inhibit abnormal macrophage activation. The macrophage is a large white blood cell that is an integral part of our immune system. Its job is to locate microscopic foreign bodies and ‘eat’ them. However, disproportional macrophage activation can induce undesirable inflammatory processes. MORE INFO

Can Patients with Chronic Infections and Autoimmune Diseases Benefit From Exosomes?

Chronic infections have a lot in common with autoimmune diseases, including dysregulated immune response incapable of protecting our body from invading pathogens (bacteria, viruses, molds etc.) while attacking its own tissues and organs thus causing significant structural damage. One of the key mechanisms controlling the direction of immune responses is a balance between specific immune cells involved in protection vs autoimmune responses, the Th17/Treg ratio. Exosomes from mesenchymal stem cells have shown to normalize the Th17/Treg ratio and bring the deviant immune response back to normal.

Can Exosomes Benefit Neurodegenerative Diseases?

Research has shown that exosomes can penetrate the blood-brain barrier and stimulate neuronal differentiation, neuronal growth, and suppress inflammatory processes within the brain tissue. MORE INFO

Exosome Therapy Cost?

The cost for exosome therapy may vary from clinic to clinic and from doctor recommendation but the National average is $5000.00 to $10,000. May be less if you work with a network like iEXOSOMES.comexosome therapy cost vs stem cell injection treatment


Exosomes Therapy vs Stem Cell Treatment




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