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Clomiphene Citrate for Men As They Age - Healthcare Quality Improvement Campaign
Effects of Clomiphene Citrate
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Clomiphene Citrate for Men As They Age

Clomiphene citrate is a drug that is rising in popularity as a possible treatment option for infertility and hypogonadism in aging males. Although it is not yet approved by the Food and Drug Administration (FDA) for those indications, many medical professionals believe clomiphene citrate may be the answer several men are looking for.

Clomiphene citrate is thought to boost testosterone levels and create more sperm, and it may also increase sperm motility in some men. Other men believe taking clomiphene citrate has other benefits such as improving their mood, increasing their energy, and enhancing their performance during exercise. 

That being said, clomiphene citrate is still only FDA-approved for the treatment of infertility in females. We need more extensive research before we can prove the efficacy of clomiphene citrate on male infertility and hypogonadism and the FDA can approve that use of the drug.

What Is Clomiphene Citrate?

Clomiphene is the short name for the drug “clomiphene citrate.” As stated above, it is a drug that is FDA-approved to treat female infertility, but it has recently gained attention as a possible treatment for infertility and hypogonadism in aging males as well. 

Clomiphene citrate works by blocking estrogen from interacting with the pituitary gland in the brain. The pituitary gland is what produces luteinizing hormone and follicle-stimulating hormone, hormones important for fertility in both males and females. When estrogen is allowed to interact with the pituitary gland, less luteinizing hormone and follicle-stimulating hormone are produced. 

So when clomiphene citrate enters the system and keeps estrogen from linking to the pituitary gland, there is an increase in the production of luteinizing hormone and follicle-stimulating hormone in the body.

In women, luteinizing hormone stimulates ovulation, and follicle-stimulating hormone prompts the ovary to produce egg follicles that will be developed and released during ovulation. In men, luteinizing hormone increases testosterone production and follicle-stimulating hormone creates more sperm. 

Because of the way clomiphene citrate affects these fertility hormones in males, some doctors have been prescribing clomiphene off-label for males with infertility or hypogonadism. “Off-label” refers to a prescription given outside the approval of the FDA—doctors will prescribe a drug off-label if they believe the benefits of the drug on the patient outweigh the risks. 

All this being said, further research must be conducted to prove the efficacy of clomiphene citrate on male infertility and hypogonadism before the FDA will be able to approve it for those indications.  

How to Use Clomiphene

As stated above, clomiphene citrate can be used in males to treat infertility and hypogonadism. However, you should take the drug with the understanding that its effectiveness against these indications is still not yet proven. You should also not use the drug for any other indications.

Clomiphene citrate is taken by mouth as directed by your healthcare provider, and you should be careful to closely abide by your dosing schedule. Dosage recommendations vary from person to person and are based on your medical condition and history. 

Because the use of clomiphene citrate to treat men with infertility or hypogonadism is still being researched, there is not any universal consensus on dosage amounts for patients. But there are some general dosage recommendations to be aware of. 

Medical professionals have observed that men may need to take clomiphene citrate for 3–4 months before they achieve the optimal results of the drug. But you do not want to take clomiphene for any longer than prescribed because long-term treatment using clomiphene is not recommended. 

Some providers of clomiphene recommend that males take the drug daily; others prescribe you to take it every few days.

Elite Health’s clomiphene product, like others, comes in oral capsule form. It should be stored at controlled room temperature. And as with other prescription medications, these clomiphene capsules should be used as prescribed by your healthcare provider. Elite Health recommends a daily dose of 1 capsule daily, unless your healthcare provider prescribes you increase the dosage to 2 capsules daily. 

Clomiphene Side Effects

There are several possible side effects of clomiphene citrate. If you experience any of the symptoms below, you should see your healthcare provider for guidance. They may lower your dosage or recommend you stop taking clomiphene citrate altogether. 

These are some of the possible side effects of clomiphene citrate: 

  • Changes in libido
  • Mood changes or irritability
  • Changes in energy level
  • Male-patterned baldness
  • Headaches
  • Vision problems
  • Dizziness
  • Nausea or vomiting
  • Stomach pain
  • Mouth ulcers
  • Breast growth or tenderness
  • Enlargement of the prostate gland
  • Mouth ulcers
  • Cataracts
  • Acne

Usually, any side effects you experience while taking clomiphene citrate can be reversed after you stop taking the medication. Again, as stated above, you should stop taking clomiphene and see your doctor for guidance if you have any of these side effects. 

Enclomiphene vs. Clomiphene Citrate

Clomiphene is used to treat male and female infertility and male hypogonadism, and some people turn to enclomiphene to treat the same conditions. When it comes down to what these two drugs are, they are structurally very similar. This is because enclomiphene is one of the two isomers that make up clomiphene (along with zuclomiphene).

An isomer is a chemical species that has the same number and types of atoms as another chemical species but with distinct characteristics because its atoms are arranged in a different chemical structure. This is the relationship between clomiphene and enclomiphene—they are made up of the same types of atoms, but they have some properties that set them apart from each other since their atoms are arranged differently. 

But what does this mean for how clomiphene and enclomiphene can treat us? How are they different? 

Where clomiphene stimulates the increase of testosterone and helps create more sperm, enclomiphene can raise testosterone levels without having any effect on sperm counts. For this reason, enclomiphene has gained attention as a possibly more effective option for treating male hypogonadism than clomiphene. 

However, like clomiphene, enclomiphene has not yet been approved by the FDA. More research needs to be conducted before we can fully understand all the effects of enclomiphene and how it might be able to treat hypogonadism in males. 

Late-Onset Hypogonadism

Hypogonadism is a condition in which the gonads (testes in males and ovaries in females) fail to function properly. One can develop hypogonadism in the fetal stages, during puberty, or as an adult. Late-onset (or adult-onset) hypogonadism is the state in which hypogonadism does not develop until later in life, after puberty. Usually, it is the result of an infection or injury.

In males, the main problem of hypogonadism is the inhibited production of testosterone. 

This problem can originate in one or both of the following places: 

  • There may be a problem in the testicles (primary hypogonadism). 
  • There may be a problem in the hypothalamus or pituitary gland of the brain (secondary hypogonadism).

As testosterone production is limited, normal reproductive functions can be hindered. It can also result in changes to masculine physical characteristics. Early symptoms of adult-onset hypogonadism in men may include decreased libido, decreased energy, and depression. 

Other signs of male late-onset hypogonadism that may arise in time include the following indications:

  • Infertility
  • Erectile dysfunction
  • Decreased growth of facial or body hair
  • Decreased muscle mass
  • Decreased bone mass (osteoporosis)
  • Development of breast tissue (gynecomastia)

There is also a point at which hypogonadism can become severe, where it begins to cause mental and emotional changes. Some men may experience symptoms similar to those that women have during menopause, including hot flashes and difficulty with concentration.

Clomiphene Citrate to Treat Hypogonadism

Clomiphene citrate has been used to treat male hypogonadism since the 1970s. As stated above, it interacts with the pituitary gland in the brain to increase the production of luteinizing hormone and follicle-stimulating hormone in the body. This leads to an increase in testosterone production, which is what the body lacks when it suffers from hypogonadism. 

The more traditional (and currently the most common) treatment of hypogonadism is testosterone replacement therapy. But more and more people are looking to clomiphene citrate to treat hypogonadism because testosterone replacement therapy has negative side effects on male infertility. 

Where clomiphene citrate helps create more sperm in addition to boosting testosterone levels, testosterone replacement therapy suppresses spermatogenesis (the body’s process to produce more sperm) as it increases testosterone. 

Therefore, men with hypogonadism who are interested in fertility may find greater benefits from using clomiphene citrate, rather than testosterone replacement therapy, to treat their hypogonadism. 

Although clomiphene citrate is still yet not approved by the FDA for the treatment of hypogonadism, many doctors still prescribe the drug off-label to treat men with hypogonadism. Additionally, some professional medical organizations, such as the American Urological Association, have published medical guidelines that support the use of clomiphene for the treatment of hypogonadism in men.

Buying Clomiphene Citrate

There are many different providers of clomiphene you can buy from, especially when you consider whether you are buying for men or women and whether you want to treat infertility or hypogonadism. For men with adult-onset hypogonadism, Elite Health is a great place to look. 

Click here to find out more about Elite Health’s Clomiphene product!

Elite Health’s clomiphene product is a specially designed formulation containing clomiphene, resveratrol, and ZMA, a supplement made up of zinc, magnesium, and vitamin B6. 

As stated above, clomiphene works by blocking estrogen from interacting with the pituitary gland in the brain, which leads to an increase in luteinizing hormone and follicle-stimulating hormone. The raised levels of these fertility hormones causes the body to produce more testosterone and create more sperm.

Resveratrol helps the body conserve the testosterone it already has, and it may help to increase testosterone levels as well. It also helps your body to maintain a healthy composition, increases antioxidant activity, contains anti-aging properties, and improves endothelial function. 

Lastly, ZMA helps increase testosterone production, as it provides the nutrients required to produce androgens like testosterone. 
Elite Health offers a 3 month supply of 90 capsules of Clom-Resv-ZMA, of which you will take 1 per day, for just $199. If you are interested in buying this product or if you want to learn more, you can schedule your free consultation today. One of our consultants will be able to answer your questions and help you place your order—all you have to do is click here!

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