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Are Fecal Transplants the Fountain of Youth for Living Healthier, Longer, and Smarter?
news release tells us that there is evidence of a “two-way communication between the gut and the brain—known as the “gut-brain axis”—that may play a role in shaping not only behavior, but our cognitive function as well, dependent on what kind of gut microbiome we carry.
“We wanted to see whether transferring gut microbes from older to younger mice could affect parts of the central nervous system associated with ageing,” says Dr. Vauzour.
What the researchers found after transferring fecal matter from older mice into the digestive tract of younger mice was that the younger mice showed no significant changes in behavior markers such as anxiety and explorative behavior, or in their locomotor activity. But what it did show was impairment in their spatial learning and memory, evidenced while performing in maze tests.
At the molecular level, the younger mice were found to have alterations in gene expression in the hippocampus part of their brains that affected the proteins associated with synaptic plasticity and neuro transmission responsible for learning and memory functioning.
“Our research shows that a fecal transplantation from an old donor to a young recipient causes an age-associated shift in the composition of gut microbiota…the procedure had an impact on the expression of proteins involved in key functions of the hippocampus—an important part of the brain that has a vital role in a variety of functions including memory, learning but also in spatial navigation and emotional behavior and mood,” says Dr.Vauzour.
